GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10808739 | 1 | rs10957323 | chr8:65680494 | CYP7B1 | chr8:65508529-65711348:- | 0.12 | 3.79 | 0.000158 | HIV-1 susceptibility |
| BRCA | cis | rs1030420 | 1 | rs10957375 | chr8:67355484 | C8orf46 | chr8:67405491-67430757:+ | -0.17 | -4.18 | 3.17E-5 | Blood metabolite levels |
| BRCA | cis | rs7267979 | 1 | rs10966 | chr20:25282944 | FAM182A | chr20:26035250-26067552:+ | -0.21 | -5.53 | 3.99E-8 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs10966 | chr20:25282944 | FAM182B | chr20:25744102-25848786:- | 0.24 | 6.35 | 3.22E-10 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs10966 | chr20:25282944 | PYGB | chr20:25228706-25278647:+ | -0.13 | -3.54 | 0.000419 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs965513 | 1 | rs10983700 | chr9:100537455 | CORO2A | chr9:100883258-100954956:- | -0.13 | -3.67 | 0.000251 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983700 | chr9:100537455 | NCBP1 | chr9:100395705-100436027:+ | -0.14 | -4.31 | 1.82E-5 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983700 | chr9:100537455 | TRIM14 | chr9:100831569-100881488:- | -0.13 | -3.6 | 0.000327 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983700 | chr9:100537455 | TSTD2 | chr9:100362364-100395962:- | -0.12 | -4.44 | 9.77E-6 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983701 | chr9:100537577 | CORO2A | chr9:100883258-100954956:- | -0.13 | -3.78 | 0.000167 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983701 | chr9:100537577 | NCBP1 | chr9:100395705-100436027:+ | -0.14 | -4.52 | 6.9E-6 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983701 | chr9:100537577 | TRIM14 | chr9:100831569-100881488:- | -0.14 | -3.71 | 0.000215 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983701 | chr9:100537577 | TSTD2 | chr9:100362364-100395962:- | -0.13 | -4.67 | 3.44E-6 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983701 | chr9:100537577 | XPA | chr9:100437192-100459691:- | -0.11 | -3.38 | 0.000739 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs10983761 | chr9:100553957 | NCBP1 | chr9:100395705-100436027:+ | -0.11 | -3.43 | 0.000636 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |